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Tech Dev 2 Technologies
Tech Dev 2 Technologies

A piggyBac-based TANGO GFP assay for high throughput screening of GPCR  ligands in live cells
A piggyBac-based TANGO GFP assay for high throughput screening of GPCR ligands in live cells

Molecules | Free Full-Text | Protective Effect of Genistein against  Compound 48/80 Induced Anaphylactoid Shock via Inhibiting MAS Related G  Protein-Coupled Receptor X2 (MRGPRX2)
Molecules | Free Full-Text | Protective Effect of Genistein against Compound 48/80 Induced Anaphylactoid Shock via Inhibiting MAS Related G Protein-Coupled Receptor X2 (MRGPRX2)

A novel luminescence-based β-arrestin membrane recruitment assay for  unmodified GPCRs | bioRxiv
A novel luminescence-based β-arrestin membrane recruitment assay for unmodified GPCRs | bioRxiv

JCI - The archaeal Dps nanocage targets kidney proximal tubules via  glomerular filtration
JCI - The archaeal Dps nanocage targets kidney proximal tubules via glomerular filtration

PRESTO-Tango as an open-source resource for interrogation of the druggable  human GPCRome | Nature Structural & Molecular Biology
PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome | Nature Structural & Molecular Biology

Demonstration of arrestin mobilization with the Tango assay. (a–f)... |  Download Scientific Diagram
Demonstration of arrestin mobilization with the Tango assay. (a–f)... | Download Scientific Diagram

Measuring GPCR Activity Using the Tango GPCR Assay on the FLIPR Tetra  Fluorimetric Imaging Plate Reader System | Molecular Devices
Measuring GPCR Activity Using the Tango GPCR Assay on the FLIPR Tetra Fluorimetric Imaging Plate Reader System | Molecular Devices

A piggyBac-based TANGO GFP assay for high throughput screening of GPCR  ligands in live cells
A piggyBac-based TANGO GFP assay for high throughput screening of GPCR ligands in live cells

Multiparametric Assays for Accelerating Early Drug Discovery: Trends in  Pharmacological Sciences
Multiparametric Assays for Accelerating Early Drug Discovery: Trends in Pharmacological Sciences

Measurement of β-Arrestin Recruitment at GPCRs Using the Tango Assay |  SpringerLink
Measurement of β-Arrestin Recruitment at GPCRs Using the Tango Assay | SpringerLink

Identification and functional characterization of arginine vasopressin  receptor 1A : atypical chemokine receptor 3 heteromers in vascular smooth  muscle | Open Biology
Identification and functional characterization of arginine vasopressin receptor 1A : atypical chemokine receptor 3 heteromers in vascular smooth muscle | Open Biology

Chemoproteomics of microbiota metabolites reveals small-molecule agonists  for orphan receptor GPRC5A | bioRxiv
Chemoproteomics of microbiota metabolites reveals small-molecule agonists for orphan receptor GPRC5A | bioRxiv

A rapid fluorogenic GPCR–β‐arrestin interaction assay - Zhang - 2018 -  Protein Science - Wiley Online Library
A rapid fluorogenic GPCR–β‐arrestin interaction assay - Zhang - 2018 - Protein Science - Wiley Online Library

A piggyBac-based TANGO GFP assay for high throughput screening of GPCR  ligands in live cells | Cell Communication and Signaling | Full Text
A piggyBac-based TANGO GFP assay for high throughput screening of GPCR ligands in live cells | Cell Communication and Signaling | Full Text

Discovery of G Protein-Biased Antagonists against 5-HT7R | Journal of  Medicinal Chemistry
Discovery of G Protein-Biased Antagonists against 5-HT7R | Journal of Medicinal Chemistry

Research Sahar El Aidy lab
Research Sahar El Aidy lab

Parallel Interrogation of β-Arrestin2 Recruitment for Ligand Screening on a  GPCR-Wide Scale using PRESTO-Tango Assay | Protocol
Parallel Interrogation of β-Arrestin2 Recruitment for Ligand Screening on a GPCR-Wide Scale using PRESTO-Tango Assay | Protocol

Engineering cell sensing and responses using a GPCR-coupled CRISPR-Cas  system. - Abstract - Europe PMC
Engineering cell sensing and responses using a GPCR-coupled CRISPR-Cas system. - Abstract - Europe PMC

A novel luminescence-based β-arrestin recruitment assay for unmodified  receptors - Journal of Biological Chemistry
A novel luminescence-based β-arrestin recruitment assay for unmodified receptors - Journal of Biological Chemistry

Addgene: Roth Lab PRESTO-Tango GPCR Kit
Addgene: Roth Lab PRESTO-Tango GPCR Kit

Tango assay for ligand-induced GPCR–β-arrestin2 interaction: Application in  drug discovery - ScienceDirect
Tango assay for ligand-induced GPCR–β-arrestin2 interaction: Application in drug discovery - ScienceDirect

Developing Photoaffinity Probes for Dopamine Receptor D2 to Determine  Targets of Parkinson's Disease Drugs | ACS Chemical Neuroscience
Developing Photoaffinity Probes for Dopamine Receptor D2 to Determine Targets of Parkinson's Disease Drugs | ACS Chemical Neuroscience

Parallel Interrogation of β-Arrestin2 Recruitment for Ligand Screening on a  GPCR-Wide Scale using PRESTO-Tango Assay | Protocol
Parallel Interrogation of β-Arrestin2 Recruitment for Ligand Screening on a GPCR-Wide Scale using PRESTO-Tango Assay | Protocol

Activation of the Orphan G Protein–Coupled Receptor GPR27 by Surrogate  Ligands Promotes β-Arrestin 2 Recruitment | Molecular Pharmacology
Activation of the Orphan G Protein–Coupled Receptor GPR27 by Surrogate Ligands Promotes β-Arrestin 2 Recruitment | Molecular Pharmacology